Balancing competing effects of tissue growth and cytoskeletal regulation during Drosophila wing disc development.

ABSTRACT: How a developing organ robustly coordinates the cellular mechanics and growth to reach a final size and shape remains poorly understood. Through iterations between experiments and model simulations that include a mechanistic description of interkinetic nuclear migration, we show that the local curvature, height, and nuclear positioning of cells in the Drosophila wing imaginal disc are defined by the concurrent patterning of actomyosin contractility, cell-ECM adhesion, ECM stiffness, and interfacial membrane tension. We show that increasing cell proliferation via different growth-promoting pathways results in two distinct phenotypes. Triggering proliferation through insulin signaling increases basal curvature, but an increase in growth through Dpp signaling and Myc causes tissue flattening.

SUBMITTER: Kumar N 

PROVIDER: S-EPMC10954670 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature