In silico approaches for the identification of potential allergens among hypothetical proteins from Alternaria alternata and its functional annotation.

ABSTRACT: Direct exposure to the fungal species Alternaria alternata is a major risk factor for the development of asthma, allergic rhinitis, and inflammation. As of November 23rd 2020, the NCBI protein database showed 11,227 proteins from A. alternata genome as hypothetical proteins (HPs). Allergens are the main causative of several life-threatening diseases, especially in fungal infections. Therefore, the main aim of the study is to identify the potentially allergenic inducible proteins from the HPs in A. alternata and their associated functional assignment for the complete understanding of the complex biological systems at the molecular level. AlgPred and Structural Database of Allergenic Proteins (SDAP) were used for the prediction of potential allergens from the HPs of A. alternata. While analy

SUBMITTER: Sundararaj R 

PROVIDER: S-EPMC10954717 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature