Causal association between mTOR-dependent circulating protein levels and central precocious puberty: a Mendelian randomization study.

ABSTRACT:

Background

The mechanistic target of rapamycin (mTOR) signaling pathway has a significant effect on central precocious puberty (CPP). However, the causality between mTOR-dependent circulating protein levels and CPP is still unclear. Our aim is to assess the effects of seven mTOR-dependent circulating protein levels on CPP using Mendelian randomization (MR).

Methods

Instrumental variables (IVs) for mTOR-dependent circulating protein levels were retrieved from the proteomics-GWAS INTERVAL study and eQTLGen. The summary-level genetic datasets for CPP outcome were obtained from the FinnGen Consortium. Inverse-variance weighted (IVW) was used as the primary method and the pleiotropy, heterogeneity and robustness of the analyses were detected as sensitivity analysis. Positive expo

SUBMITTER: Ying Y 

PROVIDER: S-EPMC10954777 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature