Mendelian randomization study shows no causal relationship between psychiatric disorders and glaucoma in European and East Asian populations.

ABSTRACT: Background: Glaucoma is a leading cause of blindness strongly associated with psychiatric disorders, but the causal association between glaucoma and psychiatric disorders remains uncertain because of the susceptibility of observational studies to confounding and reverse causation. This study aims to explore the potential causal association between glaucoma and three highly related psychiatric disorders (Depression, Insomnia, and Schizophrenia) in the European and East Asian populations using a two-sample Mendelian randomization analysis. Methods: Instrumental variables (IVs) of depression, insomnia, and schizophrenia in the European population were obtained after strict filtering. Summary-level data for glaucoma and glaucoma subtypes (primary open-angle glaucoma and primary c

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC10954835 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature