Identification of novel hub genes for Alzheimer's disease associated with the hippocampus using WGCNA and differential gene analysis.

ABSTRACT:

Background

Alzheimer's disease (AD) is a common, refractory, progressive neurodegenerative disorder in which cognitive and memory deficits are highly correlated with abnormalities in hippocampal brain regions. There is still a lack of hippocampus-related markers for AD diagnosis and prevention.

Methods

Differently expressed genes were identified in the gene expression profile GSE293789 in the hippocampal brain region. Enrichment analyses GO, KEGG, and GSEA were used to identify biological pathways involved in the DEGs and AD-related group. WGCNA was used to identify the gene modules that are highly associated with AD in the samples. The intersecting genes of the genes in DEGs and modules were extracted and the top ten ranked hub genes were identified. Finally GES48350 was us

SUBMITTER: Chen Y 

PROVIDER: S-EPMC10954837 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature