In silico and in vivo evaluation of the anti-cryptosporidial activity of eugenol.

ABSTRACT:

Background

Cryptosporidiosis is an opportunistic parasitic disease widely distributed worldwide. Although Cryptosporidium sp. causes asymptomatic infection in healthy people, it may lead to severe illness in immunocompromised individuals. Limited effective therapeutic alternatives are available against cryptosporidiosis in this category of patients. So, there is an urgent need for therapeutic alternatives for cryptosporidiosis. Recently, the potential uses of Eugenol (EUG) have been considered a promising novel treatment for bacterial and parasitic infections. Consequently, it is suggested to investigate the effect of EUG as an option for the treatment of cryptosporidiosis.

Materials and methods

The in silico bioinformatics analysis was used to predict and dete

SUBMITTER: Gattan HS 

PROVIDER: S-EPMC10954888 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature