Dataset Information

Preoperative ultrasound-guided dual localization with titanium clips and carbon nanoparticles for predicting the surgical approach and guiding the resection of Siewert type II esophagogastric junction adenocarcinoma.

ABSTRACT:

Objective

To investigate the superiority of preoperative ultrasound-guided titanium clip and nanocarbon dual localization over traditional methods for determining the surgical approach and guiding resection of Siewert type II adenocarcinoma of the esophagogastric junction (AEG).

Method

This study included 66 patients with Siewert type II AEG who were treated at the PLA Joint Logistics Support Force 900th Hospital between September 1, 2021, and September 1, 2023. They were randomly divided into an experimental group (n = 33), in which resection was guided by the dual localization technique, and the routine group (n = 33), in which the localization technique was not used. Surgical approach predictions, proximal esophageal resection lengths, pathological features, and the occurrence of complications were compared between the groups.

Result

The use of the dual localization technique resulted in higher accuracy in predicting the surgical approach (96.8% vs. 75.9%, P = 0.02) and shorter proximal esophageal resection lengths (2.39 ± 0.28 cm vs. 2.86 ± 0.39 cm, P < 0.001) in the experimental group as compared to the routine group, while there was no significant difference in the incidence of postoperative complications (22.59% vs. 24.14%, P = 0.88).

Conclusion

Preoperative dual localization with titanium clips and carbon nanoparticles is significantly superior to traditional methods and can reliably delineate the actual infiltration boundaries of Siewert type II AEG, guide the surgical approach, and avoid excessive esophageal resection.

SUBMITTER: Wu W

PROVIDER: S-EPMC10954912 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature

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Publications

Preoperative ultrasound-guided dual localization with titanium clips and carbon nanoparticles for predicting the surgical approach and guiding the resection of Siewert type II esophagogastric junction adenocarcinoma.

Wu Weihang W Luo Ziqiang Z Fang Yongchao Y Yu Li L Lin Nan N Yang Jin J Zhao Hu H Xiao Chunhong C Wang Yu Y

Journal of cancer research and clinical oncology 20240320 3

<h4>Objective</h4>To investigate the superiority of preoperative ultrasound-guided titanium clip and nanocarbon dual localization over traditional methods for determining the surgical approach and guiding resection of Siewert type II adenocarcinoma of the esophagogastric junction (AEG).<h4>Method</h4>This study included 66 patients with Siewert type II AEG who were treated at the PLA Joint Logistics Support Force 900th Hospital between September 1, 2021, and September 1, 2023. They were randomly ...[more]

PMID: 38507110

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Project description:BackgroundThe surgery of adenocarcinoma of the esophagogastric junction (AEG) is a complex procedure that increases postoperative morbidity compared to distal gastric cancer. In this study, we included thoracic anatomical parameters of patients for the first time to investigate their impact on the postoperative outcomes of transabdominal gastrectomy for Siewert type II/III AEG.MethodsAll patients with Siewert type II or III AEG of our institution who underwent transabdominal proximal or total gastrectomy from January 2015 to December 2022 were included in this study. We measured thoracic anatomical parameters on the level of the lower edge of the sternum using preoperative computer tomography. The anteroposterior diameter of the thorax was measured as the distance from the posterior edge of the sternum to the anterior edge of the spine, while the transverse diameter was the maximum distance between the ribs on both sides. Patients' data and postoperative details were retrospectively collected. Correlation between thoracic anatomical parameters with postoperative complications were analyzed.ResultsOverall, 647 patients were eligible for this study. The incidence of postoperative complications was 28.1%, with postoperative pulmonary complications occurring in 24.7%. In multivariate analysis, anteroposterior thoracic diameter > 10.2 cm was an independent risk factor for postoperative complications (OR = 1.891, 95% CI: 1.137-3.146, p = 0.014), transverse thoracic diameter > 23.3 cm was an independent risk factor for postoperative pulmonary complications (OR = 2.243, 95% CI: 1.234-4.079, p = 0.004). In open group, transverse thoracic diameter over 23.3 cm correlated independently with postoperative complications (OR = 2.451, 95% CI: 1.219-4.927, p = 0.012) and postoperative pulmonary complications (OR = 2.988, 95% CI: 1.407-6.347, p = 0.004). However, this correction was not significant in laparoscopy-assisted group.ConclusionsThoracic size is an independent risk factor affecting the postoperative outcomes of transabdominal gastrectomy for Siewert type II and III AEG. Patients with larger thoracic cage are at a higher risk of postoperative complications, particularly pulmonary complications. For those patients, laparoscopic surgery may be a viable option.

Project description:ObjectiveTo compare the prognostic factors of Siewert type II AEG patients who had received neoadjuvant radiotherapy (nRT) versus those who did not receive nRT. Nomograms for outcome prediction were constructed for the two treatment modalities.Materials and methodsData for 1,745 Siewert II type AEG patients who underwent radical surgery between 2010 and 2015 were retrieved from SEER (Surveillance, Epidemiology, and End Results) database. Patients were assigned to neoadjuvant radiotherapy (nRT) and non-neoadjuvant radiotherapy (non-nRT) groups based on treatment modality. Independent prognostic predictors were used to develop nomograms. Concordance index (C-index), receiver operating characteristic (ROC), calibration curves, and decision curve analyses (DCA) were used to determine the performance and prognostic value of the nomograms. The predictive accuracy of nomograms was compared with the prognostic value of the Tumor-Node-Metastasis (TNM) staging system.ResultsThe results showed that age, lymph node rate (LNR), and the number of removed lymph nodes (RLN) were independent prognostic factors for CSS in the nRT group. Tumor size, tumor grade, T stage, LNR, and therapy type were independent prognosis factors for CSS in patients in the non-nRT group. The C-indices for the nomograms were 0.652 (95% CI, 0.614-0.690) and 0.663 (95% CI, 0.606-0.720) in the training and validation cohort, respectively, for the nRT group. C-indices for the nomogram in non-nRT group were 0.754 (95% CI, 0.723-0.785) and 0.747 (95% CI, 0.688-0.800) for the training and validation cohorts, respectively. C-indices and ROC curves showed good predictive value compared with the TNM staging system in both groups. C-indices, as well as the AUC values of the nomograms and the TNM staging system for both cohorts in the non-nRT group were higher compared with those in the nRT group. Analysis of the survival calibration curve revealed high consistency between actual versus predicted outcomes determined by the nomograms. Decision curve analyses revealed that the new models had higher prediction value and clinical significance compared with TNM staging system.ConclusionThe established nomograms showed high prognostic value for Siewert type II AEG patients in both nRT and non-nRT groups. In addition, the nomogram and the TNM staging systems showed better prognostic performance for patients in the non-nRT group compared with patients in the nRT group.

Dataset Information

Preoperative ultrasound-guided dual localization with titanium clips and carbon nanoparticles for predicting the surgical approach and guiding the resection of Siewert type II esophagogastric junction adenocarcinoma.

Objective

Method

Result

Conclusion

Publications

Preoperative ultrasound-guided dual localization with titanium clips and carbon nanoparticles for predicting the surgical approach and guiding the resection of Siewert type II esophagogastric junction adenocarcinoma.

Similar Datasets

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