Blood T cell phenotypes correlate with fatigue severity in post-acute sequelae of COVID-19.

ABSTRACT:

Purpose

Post-acute sequelae of COVID-19 (PASC) affect approximately 10% of convalescent patients. The spectrum of symptoms is broad and heterogeneous with fatigue being the most often reported sequela. Easily accessible blood biomarkers to determine PASC severity are lacking. Thus, our study aimed to correlate immune phenotypes with PASC across the severity spectrum of COVID-19.

Methods

A total of 176 originally immunonaïve, convalescent COVID-19 patients from a prospective cohort during the first pandemic phase were stratified by initial disease severity and underwent clinical, psychosocial, and immune phenotyping around 10 weeks after first COVID-19 symptoms. COVID-19-associated fatigue dynamics were assessed and related to clinical and immune phenotypes.

Results

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SUBMITTER: Pink I 

PROVIDER: S-EPMC10954951 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature