Clostridioides difficile recurrence in individuals with and without cancer: a Swedish population-based cohort study.

ABSTRACT:

Purpose

Patients with cancer are vulnerable to Clostridioides difficile infection (CDI) due to their disease, treatment and regular hospital contact, yet if CDI-recurrence is more common remains unclear, and differences among cancer types remain unexplored.

Methods

This Swedish nationwide population-based cohort included all 43,150 individuals with recorded CDI (2006-2019) to assess CDI-recurrence in individuals with and without cancer, with binary multivariable logistic regression, stratified by anatomical location, and survival status.

Results

Compared to those without cancer (N = 29,543), ongoing cancer (diagnosis < 12 months; N = 3,882) was associated with reduced recurrence (OR = 0.81, 95% CI 0.73-0.89), while there was no association with cancer history (diagnos

SUBMITTER: Mpakaniye P 

PROVIDER: S-EPMC10954957 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature