Analysis by sex of safety and effectiveness of transvenous phrenic nerve stimulation.

ABSTRACT:

Purpose

Little is known about sex differences in the treatment of central sleep apnea (CSA). Our post hoc analysis of the remedē System Pivotal Trial aimed to determine sex-specific differences in the safety and effectiveness of treating moderate to severe CSA in adults with transvenous phrenic nerve stimulation (TPNS).

Methods

Men and women enrolled in the remedē System Pivotal Trial were included in this post hoc analysis of the effect of TPNS on polysomnographic measures, Epworth Sleepiness Scale, and patient global assessment for quality of life.

Results

Women (n = 16) experienced improvement in CSA metrics that were comparable to the benefits experienced by men (n = 135), with central apneas being practically eliminated post TPNS. Women experienced improvement in

SUBMITTER: Samii S 

PROVIDER: S-EPMC10954976 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature