Elevated ITGA1 levels in type 2 diabetes: implications for cardiac function impairment.

ABSTRACT:

Aims/hypothesis

Type 2 diabetes mellitus is known to contribute to the development of heart failure with preserved ejection fraction (HFpEF). However, identifying HFpEF in individuals with type 2 diabetes early on is often challenging due to a limited array of biomarkers. This study aims to investigate specific biomarkers associated with the progression of HFpEF in individuals with type 2 diabetes, for the purpose of enabling early detection and more effective management strategies.

Methods

Blood samples were collected from individuals with type 2 diabetes, both with and without HFpEF, for proteomic analysis. Plasma integrin α1 (ITGA1) levels were measured and compared between the two groups. Participants were further categorised based on ITGA1 levels and underwent detailed

SUBMITTER: Su M 

PROVIDER: S-EPMC10954979 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature