Drug-Gene Risk Stratification in Patients with Suspected Drug-Induced Interstitial Lung Disease.

ABSTRACT:

Background

Pulmonary toxicity has been associated with drug use. This is often not recognized in clinical practice, and underestimated.

Objective

We aimed to establish whether polymorphisms in certain genes corresponding with a metabolic pathway of drug(s) used are associated with pulmonary toxicity in patients with suspected drug-induced interstitial lung disease (DI-ILD).

Methods

This retrospective observational study explored genetic variations in three clinically relevant cytochrome P450 (CYP) iso-enzymes (i.e., CYP2D6, CYP2C9, and CYP2C19) in a group of patients with a fibroticinterstitial lung disease, either non-specific interstitial pneumonia (n = 211) or idiopathic pulmonary fibrosis (n = 256), with a suspected drug-induced origin.

Results

Of the 467 p

SUBMITTER: Drent M 

PROVIDER: S-EPMC10955005 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature