Hemophagocytic lymphohistiocytosis-how common and how severe is it as a complication of malaria? Retrospective case series and review of the literature.

ABSTRACT:

Background

Infection-associated secondary hemophagocytic lymphohistiocytosis (sHLH) is a potentially life-threatening hyperinflammatory condition caused by various infectious diseases. Malaria has rarely been described as trigger. The aim of this study is to collect data on frequency, clinical spectrum, and outcome of sHLH induced by malaria.

Methods

We collected case numbers on malaria and malaria-associated sHLH from specialized centers in Germany from 2015 to 2022. In addition, we conducted a literature search on published cases of malaria-associated sHLH and systematically analyzed the literature regarding clinical and diagnostic criteria.

Results

We obtained data from 13 centers treating 1461 malaria cases with different Plasmodium species, of which 5 patients (0

SUBMITTER: Orth HM 

PROVIDER: S-EPMC10955030 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature