Sulforaphane inhibits the growth of prostate cancer by regulating the microRNA-3919/DJ-1 axis.

ABSTRACT:

Background

Prostate cancer (PCa) is the second most common solid cancer among men worldwide and the fifth leading cause of cancer-related deaths in men. Sulforaphane (SFN), an isothiocyanate compound, has been shown to exert inhibitory effects on a variety of cancers. However, the biological function of SFN in PCa has not been fully elucidated. The objective of this study was conducted to further investigate the possible underlying mechanism of SFN in PCa using in vitro cell culture and in vivo tumor model experiments.

Methods

Cell viability, migration, invasion, and apoptosis were analyzed by Cell Counting Kit-8 (CCK-8), wound healing assay, transwell assay, or flow cytometry. Expression of microRNA (miR)-3919 was detected by quantitative real-time polymerase chain r

SUBMITTER: Zhang F 

PROVIDER: S-EPMC10955061 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature