MAIT cells are associated with responsiveness to neoadjuvant immunotherapy in COPD-associated NSCLC.

ABSTRACT:

Background

Patients with non-small cell lung cancer (NSCLC) and chronic obstructive pulmonary disease (COPD) experience worse clinical outcomes but respond better to immunotherapy than patients with NSCLC without COPD. Mucosal-associated invariant T (MAIT) cells, a versatile population of innate immune T lymphocytes, have a crucial function in the response to infection and tumors. This study investigated the distribution of MAIT cells in COPD-associated NSCLC and their involvement in the immune response.

Methods

Flow cytometry, immunohistochemistry, and immunofluorescence were performed on tissue samples of patients with NSCLC, with or without COPD, treated with or without anti-programmed death 1 (PD1) immunotherapy. MAIT cells were stimulated with 5-OP-RU using a mouse subc

SUBMITTER: Yin Y 

PROVIDER: S-EPMC10955227 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature