Genomic analysis of seven mycobacteriophages identifies three novel species with differing phenotypic stabilities.

ABSTRACT: Recently, case studies have been published regarding the application of mycobacteriophage (MP) therapy (MPT) in patients with multi-antibiotic-resistant infections. A major limitation in the development of MPT is the paucity of therapeutically useful MP. As there are approximately 10,000 MP that have yet to be sequenced, it is possible that characterization of this cohort would increase the repertoire of useful MP. This study aims to contribute to such a strategy, by characterizing a cohort of 7 mycobacteriophages. Sequencing analyses revealed that the MP have unique sequences, and subsequent gene annotation revealed differences in gene organization. Notably, MP LOCARD has the largest genome and operons encoding for glycosyltransferases. Taxonomic analysis executed with VIRIDIC, Gegenees a

SUBMITTER: O'Connell LM 

PROVIDER: S-EPMC10955285 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature