Novel biomarkers related to oxidative stress and immunity in chronic kidney disease.

ABSTRACT:

Introduction

The incidence of chronic kidney disease (CKD) has been increasing in recent years, gradually becoming a global health crisis. Due to limited treatment options, novel molecular pathways are urgently required to advance the treatment and diagnosis of CKD.

Materials and methods

The characteristics of differentially expressed genes (DEGs) in CKD patients were analyzed using Gene Expression Omnibus (GEO) database, and genes related to oxidative stress were retrieved from the Genecard database. Subsequently, a comprehensive approach was applied, including immune infiltration analysis, weighted gene co-expression network analysis (WGCNA) and protein-protein interaction (PPI) network analysis, to identify hub genes among differentially expressed immune-related oxidative

SUBMITTER: Bai F 

PROVIDER: S-EPMC10955299 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature