Identification of core gene in chronic rhinosinusitis with nasal polyps and correlations with inflammation-related genes.

ABSTRACT:

Objective

Our aim in this study is to identify the core genes of chronic rhinosinusitis with nasal polyps and analyze the correlations between it and inflammation-related genes.

Methods

GSE72713 dataset containing gene expression data of ECRSwNP, nonECRSwNP and healthy samples was obtained from Gene Expression Omnibus (GEO) and filtered by limma to identify DEGs among three groups, then the functions and correlated pathways of DEGs were analyzed using GO and KEGG. The core DEGs were selected by the intersection of DEGs and the PPI network was constructed via STRING. The correlations between the expression levels of CRSwNP core gene and inflammation-related genes were analyzed via the Mann-Whitney U test.

Results

The DEGs among ECRSwNP, nonECRSwNP, and CTRL were filter

SUBMITTER: Yang J 

PROVIDER: S-EPMC10955304 | biostudies-literature | 2024 May-Jun

REPOSITORIES: biostudies-literature