The underlying mechanisms of arenaviral entry through matriglycan.
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ABSTRACT:
SUBMITTER: Katz M
PROVIDER: S-EPMC10955480 | biostudies-literature | 2024
REPOSITORIES: biostudies-literature
Publications
The underlying mechanisms of arenaviral entry through matriglycan.
Frontiers in molecular biosciences 20240307
Matriglycan, a recently characterized linear polysaccharide, is composed of alternating xylose and glucuronic acid subunits bound to the ubiquitously expressed protein α-dystroglycan (α-DG). Pathogenic arenaviruses, like the Lassa virus (LASV), hijack this long linear polysaccharide to gain cellular entry. Until recently, it was unclear through what mechanisms LASV engages its matriglycan receptor to initiate infection. Additionally, how matriglycan is synthesized onto α-DG by the Golgi-resident ...[more]
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