Rapid and Self-Administrable Capillary Blood Microsampling Demonstrates Statistical Equivalence with Standard Venous Collections in NMR-Based Lipoprotein Analysis.

ABSTRACT: We investigated plasma and serum blood derivatives from capillary blood microsamples (500 μL, MiniCollect tubes) and corresponding venous blood (10 mL vacutainers). Samples from 20 healthy participants were analyzed by ¹H NMR, and 112 lipoprotein subfraction parameters; 3 supramolecular phospholipid composite (SPC) parameters from SPC₁, SPC₂, and SPC₃ subfractions; 2 N-acetyl signals from α-1-acid glycoprotein (Glyc), GlycA, and GlycB; and 3 calculated parameters, SPC (total), SPC₃/SPC₂, and Glyc (total) were assessed. Using linear regression between capillary and venous collection sites, we explained that agreement (Adj. R² ≥ 0.8, p < 0.001) was witnessed for 86% of plasma parameters (103/120

SUBMITTER: Roberts JL 

PROVIDER: S-EPMC10955515 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature