Expression and clinical role of PRDX6 in lung adenocarcinoma.

ABSTRACT:

Objective

To explore the levels of expression and clinical role of peroxiredoxin 6 (PRDX6) in lung adenocarcinoma.

Methods

This retrospective study used a series of bioinformatics methods to detect the levels of expression of and mutations in the PRDX6 gene in a range of cancers and lung adenocarcinoma. Immunohistochemistry was used to verify the levels of expression of PRDX6 protein in samples of lung adenocarcinoma compared with normal adjacent tissue. The effect of PRDX6 gene knockdown on the in vitro proliferation of a lung adenocarcinoma cell line was measured. Bioinformatics methods were used to determine the diagnostic value and impact on survival of the PRDX6 gene in patients with lung adenocarcinoma.

Results

The results show

SUBMITTER: Chen Z 

PROVIDER: S-EPMC10956161 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature