Cluster-specific associations between the gut microbiota and behavioral outcomes in preschool-aged children.

ABSTRACT:

Background

The gut microbiota is recognized as a regulator of brain development and behavioral outcomes during childhood. Nonetheless, associations between the gut microbiota and behavior are often inconsistent among studies in humans, perhaps because many host-microbe relationships vary widely between individuals. This study aims to stratify children based on their gut microbiota composition (i.e., clusters) and to identify novel gut microbiome cluster-specific associations between the stool metabolomic pathways and child behavioral outcomes.

Methods

Stool samples were collected from a community sample of 248 typically developing children (3-5 years). The gut microbiota was analyzed using 16S sequencing while LC-MS/MS was used for untargeted metabolomics. Parent-reported be

SUBMITTER: van de Wouw M 

PROVIDER: S-EPMC10956200 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature