APOC1 is a prognostic biomarker associated with M2 macrophages in ovarian cancer.

ABSTRACT:

Background

Recent studies have demonstrated that APOC1 is associated with cancer progression, exerting cancer-promoting and immune infiltration-promoting effects. Nevertheless, there is currently no report on the presence of APOC1 in ovarian cancer (OV).

Method

In this study, we conducted data analysis using the GEO and TCGA databases. We conducted a thorough bioinformatics analysis to investigate the function of APOC1 in OV, utilizing various platforms including cBioPortal, STRING, GeneMANIA, LinkedOmics, GSCALite, TIMER, and CellMarker. Additionally, we performed immunohistochemical staining on tissue microarrays and conducted in vitro cellular assays to validate our findings.

Result

Our findings reveal that APOC1 expression is significantly upregulated in OV compar

SUBMITTER: Yang S 

PROVIDER: S-EPMC10956310 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature