3D-printed nanohydroxyapatite/methylacrylylated silk fibroin scaffold for repairing rat skull defects.

ABSTRACT: The repair of bone defects remains a major challenge in the clinic, and treatment requires bone grafts or bone replacement materials. Existing biomaterials have many limitations and cannot meet the various needs of clinical applications. To treat bone defects, we constructed a nanohydroxyapatite (nHA)/methylacrylylated silk fibroin (MASF) composite biological scaffold using photocurable 3D printing technology. In this study, scanning electron microscopy (SEM) was used to detect the changes in the morphological structure of the composite scaffold with different contents of nanohydroxyapatite, and FTIR was used to detect the functional groups and chemical bonds in the composite scaffold to determine the specific components of the scaffold. In in vitro experiments, bone marrow mesenchymal ste

SUBMITTER: Huiwen W 

PROVIDER: S-EPMC10956317 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature