Changes in the innate immune response to SARS-CoV-2 with advancing age in humans.

ABSTRACT:

Background

Advancing age is a major risk factor for respiratory viral infections. The infections are often prolonged and difficult to resolve resulting hospitalizations and mortality. The recent COVID-19 pandemic has highlighted this as elderly subjects have emerged as vulnerable populations that display increased susceptibility and severity to SARS-CoV-2. There is an urgent need to identify the probable mechanisms underlying this to protect against future outbreaks of such nature. Innate immunity is the first line of defense against viruses and its decline impacts downstream immune responses. This is because dendritic cells (DCs) and macrophages are key cellular elements of the innate immune system that can sense and respond to viruses by producing inflammatory mediators and primi

SUBMITTER: Agrawal S 

PROVIDER: S-EPMC10956333 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature