Engineering vascularized skin-mimetic phantom for non-invasive Raman spectroscopy.

ABSTRACT: Recent advances in Raman spectroscopy have shown great potential for non-invasive analyte sensing, but the lack of a standardized optical phantom for these measurements has hindered further progress. While many research groups have developed optical phantoms that mimic bulk optical absorption and scattering, these materials typically have strong Raman scattering, making it difficult to distinguish metabolite signals. As a result, solid tissue phantoms for spectroscopy have been limited to highly scattering tissues such as bones and calcifications, and metabolite sensing has been primarily performed using liquid tissue phantoms. To address this issue, we have developed a layered skin-mimetic phantom that can support metabolite sensing through Raman spectroscopy. Our approach incorporates mi

SUBMITTER: Raj P 

PROVIDER: S-EPMC10956615 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature