Lymphatic endothelial cell-mediated accumulation of CD177⁺Treg cells suppresses antitumor immunity in human esophageal squamous cell carcinoma.

ABSTRACT: Regulatory T (Treg) cells are critical in shaping an immunosuppressive microenvironment to favor tumor progression and resistance to therapies. However, the heterogeneity and function of Treg cells in esophageal squamous cell carcinoma (ESCC) remain underexplored. We identified CD177 as a tumor-infiltrating Treg cell marker in ESCC. Interestingly, expression levels of CD177 and PD-1 were mutually exclusive in tumor Treg cells. CD177⁺ Treg cells expressed high levels of IL35, in association with CD8⁺ T cell exhaustion, whereas PD-1⁺ Treg cells expressed high levels of IL10. Pan-cancer analysis revealed that CD177⁺ Treg cells display increased clonal expansion compared to PD-1⁺ and double-negative (DN) Treg cells, and CD177⁺ a

SUBMITTER: Ma M 

PROVIDER: S-EPMC10956621 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature