Polymer-DNA assembled nanoflower for targeted delivery of dolastatin-derived microtubule inhibitors.

ABSTRACT: Dolastatin derivatives possess excellent anticancer activity and have been translated into clinical trials for cancer therapy. Drug delivery systems enable dolastatin derivatives to break the limitation of instability during blood circulation and ineffective cell internalization in the application. Nevertheless, their potential has not been thoroughly established because of the limited loading efficacy and complicated chemical modification. Herein, we rationally propose a rolling circle amplification-based polymer-DNA assembled nanoflower for targeted and efficient delivery of dolastatin-derived drugs to achieve efficient anticancer therapy. The polymer-DNA assembled nanoflower with targeted aptamer conjugate is widely applicable for loading dolastatin-derived drugs with high encapsulation

SUBMITTER: Wu T 

PROVIDER: S-EPMC10956646 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature