Longitudinal Development of Thalamocortical Functional Connectivity in 22q11.2 Deletion Syndrome.

ABSTRACT:

Background

The 22q11.2 deletion syndrome (22qDel) is a genetic copy number variant that strongly increases risk for schizophrenia and other neurodevelopmental disorders. Disrupted functional connectivity between the thalamus and the somatomotor/frontoparietal cortex has been implicated in cross-sectional studies of 22qDel, idiopathic schizophrenia, and youths at clinical high risk for psychosis. Here, we used a novel functional atlas approach to investigate longitudinal age-related changes in network-specific thalamocortical functional connectivity (TCC) in participants with 22qDel and typically developing (TD) control participants.

Methods

TCC was calculated for 9 functional networks derived from resting-state functional magnetic resonance imaging scans collected from 65 pa

SUBMITTER: Schleifer CH 

PROVIDER: S-EPMC10956688 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature