Renal graft function in transplanted patients correlates with CD45RC T cell phenotypic signature.

ABSTRACT: Biomarkers that could predict the evolution of the graft in transplanted patients and that could allow to adapt the care of the patients would be an invaluable tool. Additionally, certain biomarkers can be target of treatments and help to stratify patients. Potential effective biomarkers have been identified but still need to be confirmed. CD45RC, one of the splicing variants of the CD45 molecule, a tyrosine phosphatase that is critical in negatively or positively regulating the TCR and the BCR signaling, is one marker already described. The frequency of CD8+ T cells expressing high levels of CD45RC before transplantation is increased in patients with an increased risk of acute rejection. However, single biomarkers have limited predictive reliability and the correlation of the expression l

SUBMITTER: Bezie S 

PROVIDER: S-EPMC10956768 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature