The causal relationship between gut microbiota and immune skin diseases: A bidirectional Mendelian randomization.

ABSTRACT:

Background

Increasing evidence suggests that alterations in gut microbiota are associated with a variety of skin diseases. However, whether this association reflects a causal relationship remains unknown. We aimed to reveal the causal relationship between gut microbiota and skin diseases, including psoriasis, atopic dermatitis, acne, and lichen planus.

Methods

We obtained full genetic association summary data for gut microbiota, psoriasis, atopic dermatitis, acne, and lichen planus from public databases and used three methods, mainly inverse variance weighting, to analyze the causal relationships between gut microbiota and these skin diseases using bidirectional Mendelian randomization, as well as sensitivity and stability analysis of the results using multiple methods.

R

SUBMITTER: Feng F 

PROVIDER: S-EPMC10956797 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature