The role of GAPDH in the selective toxicity of CNP in melanoma cells.

ABSTRACT:

Background

Malignant melanoma is the most aggressive form of skin cancer with a rather poor prognosis. Standard chemotherapy often results in severe side effects on normal (healthy) cells finally being difficult to tolerate for the patients. Shown by us earlier, cerium oxide nanoparticles (CNP, nanoceria) selectively killed A375 melanoma cells while not being cytotoxic at identical concentrations on non-cancerous cells. In conclusion, the redox-active CNP exhibited both prooxidative as well as antioxidative properties. In that context, CNP induced mitochondrial dysfunction in the studied melanoma cells via generation of reactive oxygene species (primarily hydrogen peroxide (H2O2)), but that does not account for 100% of the toxicity.

Aim

Cancer cells often show an increased g

SUBMITTER: von Montfort C 

PROVIDER: S-EPMC10956844 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature