Potential causal association between leisure sedentary behaviors and osteoporosis: A two-sample Mendelian randomization analysis.

ABSTRACT: Previous observational studies have observed a correlation between sedentary behavior and osteoporosis. However, conclusions from these studies have been contradictory. To explore the potential causal relationship between sedentary behavior and osteoporosis, we conducted a Mendelian randomization analysis. A two-sample Mendelian randomization was adopted to explore the causal relationship of leisure sedentary behavior with osteoporosis. We employed 5 methods to estimate the causal associations between leisure sedentary behavior and osteoporosis. Univariable Mendelian randomization results provided evidence for the causal relationship of the time spent on computer-use with the bone mineral density estimated by heel quantitative ultrasound (eBMD) (inverse variance weighted [IVW]: β (95% conf

SUBMITTER: Chen Y 

PROVIDER: S-EPMC10956994 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature