Impaired inhibition after delta-9-tetrahydrocannabinol in women not related to circulating estradiol levels.

ABSTRACT: Cannabis and its main psychoactive constituent, delta-9-tetrahydrocannabinol (THC), impair cognitive processes, including the ability to inhibit inappropriate responses. However, responses to cannabinoid drugs vary widely, and little is known about the factors that influence the risk for adverse effects. One potential source of variation in response to cannabinoids in women is circulating ovarian hormones such as estradiol and progesterone. Whereas there is some evidence that estradiol affects responses to cannabinoids in rodents, little is known about such interactions in humans. Here, we investigate whether variations in estradiol levels across the follicular phase of the menstrual cycle modulate the effect of THC on inhibitory control in healthy women. Healthy female occasional cannabis

SUBMITTER: Pabon E 

PROVIDER: S-EPMC10957069 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature