Targeting miR-223 enhances myeloid-derived suppressor cell suppressive activities in multiple sclerosis patients.

ABSTRACT:

Background

Multiple sclerosis (MS) is an incurable autoimmune inflammatory demyelinating disease of the central nervous system. Several MS medications can modify disease course through effects on adaptive immune cells, while drugs targeting innate immunity are under investigation. Myeloid-derived suppressor cells (MDSCs) which arise during chronic inflammation, are defined by their T-cell immunosuppressive functions. MiR-223 modulates myeloid cell maturation and expansion, including MDSCs.

Methods

MDSCs isolated from healthy controls (HC) and people with MS (pwMS) were co-cultured with CD4+ T-cells to study their immunosuppressive activities in vitro. Cytokines and chemokines concentration were evaluated by Luminex assay in the serum of HC, pwMS, and other neuroinflammatory

SUBMITTER: Cantoni C 

PROVIDER: S-EPMC10957070 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature