Multiscale modeling of HBV infection integrating intra- and intercellular viral propagation to analyze extracellular viral markers.

ABSTRACT: Chronic infection with hepatitis B virus (HBV) is caused by the persistence of closed circular DNA (cccDNA) in the nucleus of infected hepatocytes. Despite available therapeutic anti-HBV agents, eliminating the cccDNA remains challenging. Thus, quantifying and understanding the dynamics of cccDNA are essential for developing effective treatment strategies and new drugs. However, such study requires repeated liver biopsy to measure the intrahepatic cccDNA, which is basically not accepted because liver biopsy is potentially morbid and not common during hepatitis B treatment. We here aimed to develop a noninvasive method for quantifying cccDNA in the liver using surrogate markers in peripheral blood. We constructed a multiscale mathematical model that explicitly incorporates both intracellula

SUBMITTER: Kitagawa K 

PROVIDER: S-EPMC10957078 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature