Candida auris undergoes adhesin-dependent and -independent cellular aggregation.

ABSTRACT: Candida auris is a fungal pathogen of humans responsible for nosocomial infections with high mortality rates. High levels of resistance to antifungal drugs and environmental persistence mean these infections are difficult to treat and eradicate from a healthcare setting. Understanding the life cycle and the genetics of this fungus underpinning clinically relevant traits, such as antifungal resistance and virulence, is of the utmost importance to develop novel treatments and therapies. Epidemiological and genomic studies have identified five geographical clades (I-V), which display phenotypic and genomic differences. Aggregation of cells, a phenotype primarily of clade III strains, has been linked to reduced virulence in some infection models. The aggregation phenotype has thus been associa

SUBMITTER: Pelletier C 

PROVIDER: S-EPMC10957086 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature