Treg cells as a protective factor for Hashimoto`s thyroiditis: a Mendelian randomization study.

ABSTRACT:

Background and objectives

Hashimoto's thyroiditis (HT), a chronic autoimmune disorder impacting thyroid function, is a growing public health concern. The relationship between Treg cells and HT has been extensively studied, with Treg cells considered crucial in suppressing HT progression. However, these studies have mainly been observational, limiting our understanding of Treg cells' impact on HT risk. Leveraging large datasets, we utilized Mendelian randomization (MR) analysis to examine the causal association between Treg cell biomarkers and HT, providing additional validation for these relationships.

Methods

Comprehensive two-sample Mendelian randomization analysis was performed to determine the causal association between Treg cells signatures and HT in this study. Based o

SUBMITTER: Guo J 

PROVIDER: S-EPMC10957564 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature