Determinants of acute kidney injury during high-power mechanical ventilation: secondary analysis from experimental data.

ABSTRACT:

Background

The individual components of mechanical ventilation may have distinct effects on kidney perfusion and on the risk of developing acute kidney injury; we aimed to explore ventilatory predictors of acute kidney failure and the hemodynamic changes consequent to experimental high-power mechanical ventilation.

Methods

Secondary analysis of two animal studies focused on the outcomes of different mechanical power settings, including 78 pigs mechanically ventilated with high mechanical power for 48 h. The animals were categorized in four groups in accordance with the RIFLE criteria for acute kidney injury (AKI), using the end-experimental creatinine: (1) NO AKI: no increase in creatinine; (2) RIFLE 1-Risk: increase of creatinine of > 50%; (3) RIFLE 2-Injury: two-fold incre

SUBMITTER: Gattarello S 

PROVIDER: S-EPMC10957825 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature