Molecular characterization of chronic cutaneous wounds reveals subregion- and wound type-specific differential gene expression.

ABSTRACT: A limited understanding of the pathology underlying chronic wounds has hindered the development of effective diagnostic markers and pharmaceutical interventions. This study aimed to elucidate the molecular composition of various common chronic ulcer types to facilitate drug discovery strategies. We conducted a comprehensive analysis of leg ulcers (LUs), encompassing venous and arterial ulcers, foot ulcers (FUs), pressure ulcers (PUs), and compared them with surgical wound healing complications (WHCs). To explore the pathophysiological mechanisms and identify similarities or differences within wounds, we dissected wounds into distinct subregions, including the wound bed, border, and peri-wound areas, and compared them against intact skin. By correlating histopathology, RNA sequencing (RNA-S

SUBMITTER: Richards SM 

PROVIDER: S-EPMC10958103 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature