Long-Term Body Mass Index Variability and Adverse Cardiovascular Outcomes.

ABSTRACT:

Importance

Body mass index (BMI; calculated as weight in kilograms divided by height in meters squared) is a commonly used estimate of obesity, which is a complex trait affected by genetic and lifestyle factors. Marked weight gain and loss could be associated with adverse biological processes.

Objective

To evaluate the association between BMI variability and incident cardiovascular disease (CVD) events in 2 distinct cohorts.

Design, setting, and participants

This cohort study used data from the Million Veteran Program (MVP) between 2011 and 2018 and participants in the UK Biobank (UKB) enrolled between 2006 and 2010. Participants were followed up for a median of 3.8 (5th-95th percentile, 3.5) years. Participants with baseline CVD or cancer were excluded. Data were ana

SUBMITTER: Almuwaqqat Z 

PROVIDER: S-EPMC10958234 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature