The T1-weighted/T2-weighted ratio as a biomarker of anti-NMDA receptor encephalitis.

ABSTRACT:

Background

Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis rarely causes visible lesions in conventional MRI, yet advanced imaging detects extensive white matter damage. To improve prognostic capabilities, we evaluate the T1-weighted/T2-weighted (T1w/T2w) ratio, a measure of white matter integrity computable from clinical MRI sequences, in NMDAR encephalitis and examine its associations with cognitive impairment.

Methods

T1-weighted and T2-weighted MRI were acquired cross-sectionally at 3 Tesla in 53 patients with NMDAR encephalitis (81% women, mean age 29 years) and 53 matched healthy controls. Quantitative and voxel-wise group differences in T1w/T2w ratios and associations with clinical and neuropsychological outcomes were assessed. P-values were false discovery ra

SUBMITTER: Hartung TJ 

PROVIDER: S-EPMC10958321 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature