Potential actions of capsaicin for preventing vascular calcification of vascular smooth muscle cells in vitro and in vivo.

ABSTRACT: Vascular calcification (VC) is an accurate risk factor and predictor of adverse cardiovascular events; however, there is currently no effective therapy to specifically prevent VC progression. Capsaicin (Cap) is a bioactive alkaloid isolated from Capsicum annuum L., a traditional medicinal and edible plant that is beneficial for preventing cardiovascular diseases. However, the effect of Cap on VC remains unclear. This study aimed to explore the effects and related mechanisms of Cap on aortic calcification in a mouse and on Pi-induced calcification in vascular smooth muscle cells (VSMCs). First, we established a calcification mouse model with vitamin D3 and evaluated the effects of Cap on calcification mice using von Kossa staining, calcium content, and alkaline phosphatase activity t

SUBMITTER: Yan YF 

PROVIDER: S-EPMC10958412 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature