Development and Validation of a Protein Risk Score for Mortality in Heart Failure : A Community Cohort Study.

ABSTRACT:

Background

Heart failure (HF) is a complex clinical syndrome with high mortality. Current risk stratification approaches lack precision. High-throughput proteomics could improve risk prediction. Its use in clinical practice to guide the management of patients with HF depends on validation and evidence of clinical benefit.

Objective

To develop and validate a protein risk score for mortality in patients with HF.

Design

Community-based cohort.

Setting

Southeast Minnesota.

Participants

Patients with HF enrolled between 2003 and 2012 and followed through 2021.

Measurements

A total of 7289 plasma proteins in 1351 patients with HF were measured using the SomaScan Assay (SomaLogic). A protein risk score was derived using least absolute shrinkage and selec

SUBMITTER: Kuku KO 

PROVIDER: S-EPMC10958437 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature