Endurance exercise preserves physical function in adult and older male C57BL/6 mice: high intensity interval training (HIIT) <i>versus</i> voluntary wheel running (VWR).

ABSTRACT: Exercise has been shown to improve physical function, mitigate aspects of chronic disease and to potentially alter the trajectory of age-related onset of frailty and sarcopenia. Reliable and valid preclinical models are necessary to elucidate the underlying mechanisms at the intersection of age, exercise, and functional decline. The purpose of this study was to compare, head to head, the effects of two common pre-clinical models of endurance exercise: high intensity interval training (HIIT) and voluntary wheel running (VWR). The hypothesis was that a prescribed and regimented exercise program, HIIT, would prove to be a superior training method to unregulated voluntary exercise, VWR. To investigate this hypothesis, we evaluated adult (n = 24, designated 10 m, aged 6 months at the beginning

SUBMITTER: Pajski ML 

PROVIDER: S-EPMC10958787 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature