HPV-associated cervicovaginal microbiome and host metabolome characteristics.

ABSTRACT:

Background

Cervicovaginal microbiome plays an important role in the persistence of HPV infection and subsequent disease development. However, cervicovaginal microbiota varied cross populations with different habits and regions. Identification of population-specific biomarkers from cervicovaginal microbiota and host metabolome axis may support early detection or surveillance of HPV-induced cervical disease at all sites. Therefore, in the present study, to identify HPV-specific biomarkers, cervicovaginal secretion and serum samples from HPV-infected patients (HPV group, n = 25) and normal controls (normal group, n = 17) in Xichang, China were collected for microbiome (16S rRNA gene sequencing) and metabolome (UHPLC-MS/MS) analysis, respectively.

Results

The results showed that

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC10958955 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature