Shengu granules ameliorate ovariectomy-induced osteoporosis by the gut-bone-immune axis.

ABSTRACT:

Introduction

Postmenopausal osteoporosis (PMOP) is a common chronic disease, and the loss of bone density and bone strength after menopause are its main symptoms. Effective treatments for PMOP are still uncertain, but Chinese medicine has some advantages in slowing down bone loss. Shengu granules are often used clinically to treat PMOP. It has been shown to be an effective prescription for the treatment of PMOP, and there is evidence that gut flora may play an important role. However, whether Shengu granules attenuate PMOP by modulating gut flora and related mechanisms remains unclear.

Methods

In this study, we mainly examined the bone strength of the femur, the structure of the intestinal microbiota, SCFAs in the feces and the level of FOXP3 cells in the colon. To further l

SUBMITTER: Chen XC 

PROVIDER: S-EPMC10959285 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature