Dataset Information

Hyalangiumruber sp. nov, characterization of a novel myxobacterium strain s54d21 and their secondary metabolites.

ABSTRACT: Myxobacteria are special bacteria with wide adaptability, which are rich sources of structurally diverse natural products with intriguing biological properties. Here, a gram-negative myxobacterium strain s54d21^T was isolated from the sediment of a wetland park in China using the Escherichia coli baiting method. Based on 16S rRNA gene sequence and genomic data, the strain was demonstrated to be a novel species of a rare genus Hyalangium, designated Hyalangium ruber sp. nov (type strain s54d21^T = GDMCC 1.1945^T = JCM 39263^T). The subsequent chemical investigation of the strain s54d21^T led to the isolation of three rare 3,5,6-trisubstituted 2(1H)-pyrazinones, namely, hyalanones A-C (1-3), together with a known macrolactin A (4). Those new structures and their absolute configurations were unambiguously assigned by extensive analyses of spectroscopic data and density functional theory (DFT) calculations. In biological assays, compound 4 exhibited moderate cytotoxic activities against human cell lines RKO, A549, and NCM460 with IC₅₀ values ranging from 27.21 to 32.14 μM.

SUBMITTER: Zang Y

PROVIDER: S-EPMC10959286 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature

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Hyalangiumruber sp. nov, characterization of a novel myxobacterium strain s54d21 and their secondary metabolites.

Zang Yi Y Zhang Xianjiao X Wang Zhe Z Tong Qingyi Q Zhou Yang Y Yao Qing Q Zhu Honghui H

Frontiers in microbiology 20240308

Myxobacteria are special bacteria with wide adaptability, which are rich sources of structurally diverse natural products with intriguing biological properties. Here, a gram-negative myxobacterium strain s54d21T was isolated from the sediment of a wetland park in China using the Escherichia coli baiting method. Based on 16S rRNA gene sequence and genomic data, the strain was demonstrated to be a novel species of a rare genus Hyalangium, designated Hyalangium ruber ...[more]

PMID: 38525079

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Hyalangiumruber sp. nov, characterization of a novel myxobacterium strain s54d21 and their secondary metabolites.

Publications

<i>Hyalangium</i><i>ruber</i> sp. nov, characterization of a novel myxobacterium strain s54d21 and their secondary metabolites.

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