The interplay of family history of depression and early trauma: associations with lifetime and current depression in the German national cohort (NAKO).

ABSTRACT:

Introduction

Family history of depression and childhood maltreatment are established risk factors for depression. However, how these factors are interrelated and jointly influence depression risk is not well understood. The present study investigated (i) if childhood maltreatment is associated with a family history of depression (ii) if family history and childhood maltreatment are associated with increased lifetime and current depression, and whether both factors interact beyond their main effects, and (iii) if family history affects lifetime and current depression via childhood maltreatment.

Methods

Analyses were based on a subgroup of the first 100,000 participants of the German National Cohort (NAKO), with complete information (58,703 participants, mean age = 51.2 years,

SUBMITTER: Streit F 

PROVIDER: S-EPMC10959537 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature