Protocol for two models of behavioral transition from action to no-action when facing prolonged uncontrollable experience in mice.
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ABSTRACT:
SUBMITTER: Li C
PROVIDER: S-EPMC10959713 | biostudies-literature | 2024 Mar
REPOSITORIES: biostudies-literature
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Protocol for two models of behavioral transition from action to no-action when facing prolonged uncontrollable experience in mice.
Li Chaoqun C Zhang Ying Y Sun Tianping T Abumaria Nashat N
STAR protocols 20240315 2
Uncontrollability could lead to behavioral adjustment or even giving up when facing repeated failure. Here, we detail a protocol to study the behavioral transition from action to no-action induced by prolonged uncontrollable experiences in mice. We describe the behavioral devices, video analysis, and the exponential learning curve fitting for mathematical assessment. We perform further validation experiments evaluating locomotor, social, and anxiety-/depression-like behaviors. This approach help ...[more]
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